REVIFERT

INFERTILITY

Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or still births, that’s also called infertility.

Infertility in general can be classified as:

  1. Male Infertility
  2. Female Infertility

Infertility affects approximately 1 out of every 6 couples. An infertility diagnosis is given to a couple who are unable to conceive over the course of one year. When the problem lies with the male partner it is referred to as male infertility. Male infertility factors contribute to approximately 30% of all infertility cases, and male infertility alone accounts for approximately one-fifth of all infertility cases.

Male infertility

Male infertility can be defined as an inability to induce conception, due to defect in spermatic functions. Males were considered infertile with sperm parameters and the 

most significant of these are reduced no. of Spermatozoa (Oligozoospermia), reduced sperm motility (Asthenozoospermia), reduced sperm vitality (Necrozoospermia), abnormal sperm morphology (Teratozoospermia) or any combination of these.

Some common causes of male infertility

  1. Abnormal sperm production or function- Sperm abnormalities may be caused by inflammation of the testicles, swollen veins in the scrotum and abnormally developed testicles.
  2. Ejaculation problems- Premature ejaculation, retrograde ejaculation (when the semen is forced back into the bladder), erectile dysfunction.
  3. Hormone imbalances- Infertility can result from disorders of the testicles themselves or an abnormality affecting other hormonal systems including the hypothalamus, pituitary, thyroid and adrenal glands. Low testosterone (male hypogonadism) and other hormonal problems have a number of possible underlying causes.
  4. Certain medications- Testosterone replacement therapy, long-term anabolic steroid use, cancer medications (chemotherapy), certain antifungal medications, some ulcer drugs and certain other medications can impair sperm production and decrease male fertility.
  5. Other issues- Anatomical abnormalities such as having a urethral opening beneath the penis (hypospadias), psychological and relationship problems, any injury or infection in reproductive organ, bad lifestyle, overexposure to certain things like heat, chemicals and alcohol etc.

Common infertility issues

Male infertility usually manifests as issues with the sperm or with the process of ejaculation. These issues can take many forms, but the most common problems seen by fertility specialists include:

Azoospermia: This condition is defined as the complete absence of sperm in the semen. It may be that the body is not producing any sperm, but more often it is a result of a blockage or obstruction in the ejaculatory ducts or vas deferens. This can prevent any sperm from leaving the testicles and reaching the ejaculate. 

Oligospermia: Oligospermia means that there are very few sperm cells in the ejaculate or “low sperm count”. This could be caused by low sperm production or by a partial ejaculatory ducts or vas deferens obstruction. 

Congenital absence of the vas deferens: In some cases, the tubes which transport sperm to the penis in the event of ejaculation do not develop before birth.  A patient who has this condition may actually be producing viable sperm in the testes. However, without a way to travel to the ejaculate, pregnancy becomes impossible.

Ejaculatory duct obstruction (EDO): It is a blockage in a man’s ejaculatory ducts may be caused by an injury or infection, or it may be a congenital issue which has been present since birth. 

Varicocele: Some men develop enlarged varicose veins in the scrotum. This can affect the reproductive function in several ways, any of which may impact sperm production, quality, and transport. 

Poor sperm motility (Asthenozoospermia) or morphology (Teratozoospermia): Sometimes a man is producing a good quantity of sperm, but there are issues with how the sperm are shaped (morphology) or how they move (motility). These problems can mean that the sperm has a hard time reaching or penetrating the egg.

Previous vasectomy: This is a straight forward cause of infertility, where a man who underwent a vasectomy (surgical procedure for male sterilization) at an earlier point in his life now wishes to conceive.

Premature ejaculation: If a man consistently ejaculates before vaginal penetration (which can be caused by prostate health issues, mental health issues, and certain medications) the chances of a sperm meeting an egg are very low.

Erectile dysfunction: Consistent trouble achieving or maintaining an erection (often due to medical issues) can make conceiving extremely difficult or even impossible. 

 

MALE INFERTILITY ACCORDING TO AYURVEDA

In Ayurveda sperm is called as Shukra which considered as one of the Dhatu and is assigned with the function of best owing the progeny.

Causes of male infertility according to Ayurveda: Vitiation of Tridoshas; impaired agni, impaired production of Dhatu (Rasa to Shukra) all these factors impair the shukradhatu. Ayurveda explains sukradushti (seminal abnormalities) & Klaibya (sexual dysfunction), main reason for the male infertility. Intake of ruksha, tikta, kashya, atilavana, amla and ushna ahar and anxiety, sadness or old age are some other causes of Shukradushti.

Mainly Vatadosha along with Pitta undergo vitiation and the normal qualities and quantity of the Shukradhatu is deranged. As a result of the vitiation of Vata and Pitta dosha the channels which carry Shukra (Shukravaha strotas) under goes Dushti, which in capacitates one normal individual from conceiving his life partner, ending in infertility.

In Ayurvedic pharmacology, Rasayana (rejuvenators) and vajikarana/ Vrishya (aphrodisiac) herbs aids nourishment and stimulate the sexual tissues.

Vajikaran therapy helps to revitalize all seven dhatus and restores equilibrium and health. It minimizes the shukra defects and ensures a healthy progeny. Rasayana drugs replenish the vital fluids of our body. The Rasayana therapy enhance the qualities of rasa, enriches it with nutrients so one can attain longevity, memory, intelligence, youthfulness, optimum development of physique and sense organs.

Each capsule contains:

Aqueous extract derived from: Ashwagandha 325mg, Varahikand 325mg, Giloy 275mg, Kapikacchu 250mg, Shweta Musali 250mg, Shtawari 250mg, Shalmali 250mg, Vidarikand 96mg, Gokhru 96mg, Amlaki 48mg

Powders of: Kokilaksha 96mg, Shilajeet shudha 48mg, Bhallataka shudha 24mg, Jaiphala 24mg, Poorana Chandra Rasa 24mg, Praval pishti 20mg, Vanga Bhasma 16mg, Sounth 8mg, Pippali 8mg

Ashwagandha (Withania somnifera)

Ashwagandha is widely utilized in Ayurveda as a rasayana (or rejuvenating) tonic that restores strength from within. Owing to it stress relieving, relaxing effect on the body and mind, as well as fortifying of all the dhatus, it is considered as the best herb to target many of the contributing factors that are associated with reduced sexual energy. Its root extract is used to treat sexual weakness, erectile dysfunction, and performance anxiety in men. According to some studies:

  • Withania somnifera root powder when administered to normozoospermic infertile man for 3 months showed a significant reduction in stress, improved antioxidants, and enhanced semen volume.
  • The aqueous extract of this herb has been shown to improve spermatogenesis, owing to elevated interstitial cell stimulating hormone and testosterone-mimicking effects together with induction of nitric oxide synthase.

Varahikand (Dioscorea bulbifera)

Varahikand possesses profound therapeutical potency attributed with Vrushya (Aphrodisiac), Balya (strength promoting), Rasayana (Rejuvinative) karmas.

 Kapikacchu (Mucuna pruriens)

  • In a study, pruriens has been shown to efficiently recover the spermatogenic loss which was induced in male rats by ethinylestradiol administration. 
  • The seed extract of M. pruriens showed marked improvement in sexual potency and behavior, libido, sperm parameters, and endocrine levels.
  • In a clinical study, pruriens seeds increased sperm concentration and motility in all the infertile groups, the levels of lipids, antioxidant vitamins and corrected fructose were recovered after a decrease in lipid peroxides after treatment. Bio Med Research International. Vol 2014, 19 pages.

Shatavari (Asparagus racemosus)

Shatavari can serve as a powerful male tonic. With a bittersweet taste, this herb renders cooling and purifying effect to the liver and blood and targets pitta at its main site in the small intestine. Its cooling properties balance the heating herbs which are used to improve sperm count. Thus, Shatavari prevents depletion of sperm caused by burning via excess pitta.

General fatigue, low sexual energy, anger, stress, irritability, inflammation, hyperacidity, urogenital infections, burning sensations etc. are the conditions when this herb can be used as drug in standardized dose.

Pippali (Piper longum)

Pippali is a rejuvenating herb with a stimulating action. Its oily nature prevents it from drying making it suitable for vata and its pleasant post digestive effect makes it more calming to pitta than other hot spices and herbs.

Shilajit (Asphaltum punjabianum)

Shilajit is immensely important Ayurvedic herb which, increases virility and sexual stamina via removing excess kapha, while maintaining the normal genital tone. In kapha related reproductive imbalances, it is used in combination with Ashwagandha.

In a study the aphrodisiac and spermatogenic potential of the extract of Shilajit was evaluated in rats and it is concluded that Shilajit can be useful in the treatment of certain forms of sexual inadequacies, such as premature ejaculation and oligospermia.

 Gokhru (Tribulus terrestris)

It is regarded as an aphrodisiac since ancient times. Administration of T. terrestris to animals showed to improve plasma testosterone level and induced spermatogenesis. It increases sexual behavior evident through increase in mount frequency and intromission frequency, reduction in mount latency, intromission latency, and penile erection index as well as increase in prostate weight and intracavernosal pressure.

Shweta Musli (Asparagus adscendens)

The aqueous extract of dried roots of this herb enhanced sexual arousal, strength, and libido as well as sperm count in Wistar male rats. Extract of this herb showed anabolic and spermatogenic effect in treated male rats.

Sounth (Zingiber officinale)

In a study, Administration of ginger for 22 consecutive days significantly increased Sperm motility and viability in both experimental groups as compared with the control group. The lumen in experimental groups the seminiferous tubules showed a significant increase in the luminal spermatozoa.Journal of Advances in Biology, Volume 8 Number 2, 1607-1611.

Shalmali (Bombax ceiba)

Bombax ceibais is used traditionally in Indian subcontinent as sexual stimulant. In an animal study, treatment with B. ceiba extract had a pronounced effect on sexual behaviour. A significant increase in mount, intromission and ejaculation frequency was observed in case of B. ceiba treated animals. Mount latency time that is an indicator of physical exhaustion during a sexual act was reduced by 38% in B. ceiba treated and 34% in testosterone-treated group as compared to control group. Intromission (IL) and PEL time was reduced by 34% in B. ceiba treated group whereas only 17% reduction was observed in testosterone-treated group. Reduced IL and PEL have been correlated with invigoration of endocrine system thereby, resulting in enhanced sexual performance and motivation.Andrologia 2012, 44, 474–478

Amlaki (Emblica officinalis)

Amalaki is one of the greatest rejuvenators and a powerful natural antioxidant. It also helps to boost the immune system. Amla pacifies all the three dosha - vata, pitta and kapha - it has a wide range of corrective and curative effects on the human body.

A laboratory study indicates that E. officinalia plays a core role to reduce the Chlorpyrifos (Fertilizer) toxicity in male reproductive aspect. When the subjects were treated with E. officinalis in conjugation with Chlorpyrifos, the parameters like body weight, male reproductive organ weight, sperm count, sperm morphology, ACP, ALP, total protein, uric acid and serum testosterone exhibited recovery and when treated with E. officinalis alone, these parameters were near to the control group that highlights the scavenging property of E. officinalis.Springer Plus 2013, 2:541

Kokilaksha (Asteracantha longifolia)

In a study, the effect of seeds of A.longifolia on the sexual behaviour of male albino rats was evaluated. The extract of seeds of A. longifolia was administered to groups of rats for a period of 28 days. The ethanolic extract exhibited pronounced anabolic effects in treated animals. Increased spermatogenesis due to treatment with extracts was also witnessed in transverse section. A significant increase in the sperm count as well as fructose levels of seminal vesicles was noted.Natural Product Research. Vol. 25, No. 15, September 2011, 1423–1431

Giloy (Tinospora cordifolia)

In Ayurveda, Giloy has been used since long for its Rasayana properties to increase the vigor and immunity. Pharmacological properties of T. cordifolia are Deepana (ability to facilitate metabolism) and Tridosha Shamaka (helps to maintain body humors). T. cordifolia is known as an adaptogen, as it increases the resistance of the body to physical, chemical, and biological stress and builds energy and general vitality. In many preclinical and clinical studies, T. cordifolia has shown following properties, such as anti-stress, immunostimulatory, anti-inflammatory, antihyperlipidemic and antioxidant

Vidarikand (Pueraria tuberosa)

The tuberous roots of this plant are used in Indian traditional medicine (Ayurveda) in general debility, spermatorrhoea and burning sensation. It strengthens body and boosts immunity. It rejuvenates the male reproductive system and increases both quality and quantity of semen by increasing its count and mobility. It reduces vatapitta and normalizes kapha, which increases shukradhatu. This shukradhatu helps in increasing hard erections, libido and sexual energy.

Bhallataka Shudha (Semecarpus anacardium)

In an experimental study, the sexual improving effect of Bhallataka on normal male rat was conducted. The extract of bhallatak was administrated to male mice and they were found to stimulate the mounting behaviour of mice, and also significantly increase their mating performance. The extract of bhallataka enhanced the sexual behaviour of the male mice.Int. Res. J. Pharm. 2013, 4(4)

Jaiphala (Myristica fragrans):

In an experimental study, the extract of Jaiphala showed significant increase in aphrodisiac properties in mice such as increase in mating frequency, libido and potency. The extract was also observed to be devoid of any adverse effects and acute toxicity. It has also been used in Unani medicine for the treatment of sexual disorders.BMC Complementary and Alternative Medicine 2005, 5:16

Purnachandra Rasa:

Purnachandra Rasa is an Ayurvedic formulation containing herbo mineral compounds. In a study, Spermatogenic activity of Purnachandra Rasa was evaluated experimentally on albino rats. Purnachandra Rasa produced significant increase in weight of reproductive organs as compared to Normal group, Negative group & Standard group. The sperm counts in Cauda epididymis were significantly increased in Test Groups. It is concluded that administration of Purnachandra Rasa suggested increased Spermatogenic activity.PIJAR.July-August-17,volume 1,Issue-6. 102-112

Praval Pishti:

The continuous usage of praval pishti helps in improving the functions of the immune system properly. It strengthens the male reproductive system, useful in spermatorrhoea and sexual function. Praval Pisthi is highly beneficial for reducing this type of fatigue and tiredness. It also reduces body ache and general weakness that occurs after infection.

Vanga Bhasma:

In a study, the efficacy of Vanga Bhasma as Vrishya on the basis of seminal parameters, sexual dysfunction, and quality of sexual life was evaluated. The study was conducted on 30 male subjects. Statistically significant improvement was observed on total sperm count and semen volume. Highly significant improvement was observed on abnormal sperm forms and sperm motility. In terms of subjective parameters also, highly significant improvement was observed in sexual desire, rigidity, ejaculation, erection and orgasm. The study revealed that Vanga Bhasma can be used as a Vrishya drug. Int. J. Res. Ayurveda Pharm. 5(4), Jul - Aug 2014

Male infertility refers to male's inability to cause pregnancy in a fertile female which is commonly due to abnormality and poor quality of the semen. According to Ayurveda, Mainly Vata dosha along with Pitta undergo vitiation and the normal qualities and quantity of the Shukra dhatu is deranged. As a result of the vitiation of Vata and Pitta dosha, the channels which carry Shukra (Shukravahastrotas) under goes Dushti.

Revifert is the Ayurvedic formulation prepared by the combination of Rasayan and Vajikaran herbs that helps in the management of male sexual health by improving the semen quality by balancing vitiated dosha (Body Humours).

  • The natural ingredients of Revifert possess tonic and aphrodisiac properties which are beneficial in treating impotency due to seminal debilities.
  • Vanga bhasma, Purnachandra rasa, Kokilaksha and Sonth in Revifert works as Spermatogenic that increases Sperm count, sperm motility, viability and sperm quality.
  • Ashwagandha, Varahikand, and Shilajit restore vigor, vitality and improve sexual performance.
  • Revifert stimulates, rejuvenates and nourishes the male reproductive tissues for production of healthy progeny.