ANDEMAC TABLET

DEPRESSION

Depression is a state of low mood and aversion to activity that can affect a person’s thoughts, behavior, feelings and sense of well-being. Depressed people may feel sad, anxious, empty, hopeless, worried, helpless, worthless, guilty, irritable, hurt, or restless. It is the result of chemical imbalance in the brain.

  1. Major depressive disorder, or major depression –Disabling and prevents a person from normal functioning. Interfere with a person’s ability to work, sleep, study, eat, and enjoy once-pleasurable activities.
  2. Dysthymic disorder, or dysthymia-Long-term (2 years or longer) symptoms that may not be severe enough to disable a person but can prevent normal functioning or feeling well.
  3. Minor depression- Having symptoms for 2 weeks or longer that does not meet full criteria for major depression.

Some forms of depression are slightly different, or they may develop under unique circumstances. They include:

  1. Psychotic depression, which occurs when a person has severe depression plus some form of psychosis, such as having disturbing false beliefs or a break with reality (delusions), or hearing or seeing upsetting things that others cannot hear or see (hallucinations).
  2. Postpartum depression, which many women experience after giving birth, when hormonal and physical changes and the new responsibility of caring for a newborn can be overwhelming.
  3. Seasonal affective disorder (SAD), which is characterized by the onset of depression during the winter months, when there is less natural sunlight. The depression generally lifts during spring and summer.
  4. Bipolar disorder, also called manic-depressive illness, is not as common as major depression or dysthymia. Bipolar disorder is characterized by cycling mood changes—from extreme highs (e.g., mania) to extreme lows (e.g., depression).

ANXIETY

Anxiety is an unpleasant state of inner turmoil, often accompanied by nervous behavior, such as pacing back and forth, and somatic complaints. It is often accompanied by restlessness, fatigue, problems in concentration, and muscular tension.

Most common anxiety disorders:

  1. Generalized anxiety disorder (GAD) is an anxiety disorder that is characterized by excessive, uncontrollable and often irrational worry about everyday things that is disproportionate to the actual source of worry. Symptoms must last at least six months. Symptoms including fatigue, headaches, nausea, numbness in hands and feet, muscle tension, muscle aches, difficulty swallowing, bouts of difficult breathing, difficulty in concentrating, trembling, twitching, irritability,  agitation sweating, restlessness, insomnia, hot flashes, rashes and inability to fully control the anxiety.
  1. Obsessive-Compulsive disorder (OCD) recurring irrational thoughts that lead you to perform specific, repeated behaviors. Symptoms include excessive washing or cleaning; repeated checking. However, OCD sufferers generally recognize their obsessions and compulsions as irrational and may become further distressed by this realization.
  1. Panic disorder is an anxiety disorder characterized by recurring severe panic attacks. A person with panic disorder may live in fear of the next panic attack. It is not the same as agoraphobia (fear of public places). Although many afflicted with panic disorder also suffer from agoraphobia. Panic disorder may be differentiated as a medical condition, or chemical imbalance.
  1. Post-Traumatic Stress Disorder (PTSD) may develop after a person is exposed to one or more traumatic events, such as sexual assault, serious injury or the threat of death. Symptoms such as disturbing recurring flashbacks, avoidance or numbing of memories of the event, and hyper arousal (high levels of anxiety) continue for more than a month after the traumatic event. Women are more likely to develop PTSD than men.
  1. Social Anxiety Disorder (SAD) or (Social phobia) is the most common anxiety disorder. It is characterized by intense fear in social situations, causing considerable distress and impaired ability to function in at least some parts of daily life. These fears can be triggered by perceived or actual scrutiny from others. Symptoms include excessive blushing, sweating, trembling, palpitations and nausea. Stammering may be present, along with rapid speech. Panic attacks can also occur under intense fear and discomfort.

         SAD is sometimes referred to as an ‘illness of lost opportunities’. Symptoms of anxiety can range in number, intensity,               and frequency, depending on the person.

  1. Separation anxiety disorder is fear of being away from home or loved ones.
 

ANXIETY AND DEPRESSION ACCORDING TO AYURVEDA

Anxiety and depression are the mental disorders known as Manasvikar or Manasroga . According to Ayurveda, person is said to be healthy when they enjoy balance between sharirik and manasik dosha, of energies produced in the body (samaganischa), tissues in the organs (samadhatu) combined with proper elimination of mala from our body (malakriya), a happy atma (prasannatma), happy of functioning mind (prasannamanaha) and proper functioning of five senses (samaindriyas).

Ayurveda described three Manasgunas, i.e. Satwa, Rajas, Tama. If there is imbalance between the Satva, Raja and Tama then it can lead to disease by vitiation of Manas Guna’s and becomes manas Dosha except the Satva guna. Acharaya Charak has mentioned that vitiated vata, pitta and kapha (dosha of sharira) circulate in entire body through the shrotas (circulatory channels of the body) along with manasika doshas, causes mental illness.

Some Manshika Vikaras describes in Ayurveda:

  • Unmada (Psychosis)
  • Apasmara (Epilepsy)
  • Bhrama (illusion)
  • Avasada (Depression)
  • CittoUdvega (Anxiety disorder)
  • Vibhrama (Delusion)

Ayurveda is believed to cure human diseases through establishment of equilibrium in the different elements of human life, the body, the mind, the intellect and the soul. Use of Medhya Rasayana drugs is a unique method of treatment described in Ayurveda for mental illness. Those specific to brain tissues called Medhya Rasayana. They are claimed to promote cognitive functions of the brain and helps in regeneration of neural tissues besides producing anti-stress and memory enhancing effect and retards brain aging. The mode of Medhya rasayana therapy involves the individual to attain sedation, calmness, tranquility or a stimulation of activities of brain. Medhya rasayana drugs are used for prevention and treatment of mental disorders of all age groups.

Medhya rasayan drugs promote “Buddhi” and “Manas” by correcting the disturbances of “Raja” and “Tama”. This helps the mentally disturbed patients to get relief from stress, anxiety and depression.

Each tablet contains:

Mass extract derived from: Mandukparni 300mg, Yashtimadhu 300mg, Ashwagandha  300mg, Vacha 300mg, Sugandhbala 250mg, Amla 100mg

Powders of: Jatamamsi 50mg, Ashwagandha 200mg

Bhavana: Brahmi (qs)

Mandukparni (Centella asiatica)

In ayurveda it is described under the Medhya rasayana drugs with pitta kapha shamak properties. It is a neuroprotective agent used traditionally since decades in ayurvedic medicine.

In a clinical study, the extract of Centella asiatica (CA) on generalized anxiety disorder (GAD) was evaluated. Thirty-three participants were medicated with the CA The observations revealed that, CA not only significantly attenuated anxiety related disorders but it also significantly reduced stress phenomenon and its correlated depression. CA further significantly improved the willingness for adjustment and cognition. Nepal Med Coll J. 2010 Mar;12(1):8-11.

 Ashwagandha (Withania somnifera)

Research conducted at the Department of Pharmacology; University of Texas Health Science Center indicated that extracts of Ashwagandha produce GABA-like activity, owing to its anxiolytic effect. Studies conducted on laboratory model showed that Ashwagandha produced an increase in the levels of three natural anti-oxidants (superoxide dismutase, catalase and glutathione peroxidase).

In another study, the anti-stress activity of W. somnifera on cold swimming stress was evaluated and the results indicates a significant increase in the plasma corticosterone level, phagocytic index and avidity index in rats subjected to cold swimming stress. In the rats pretreated with the drug, these parameters were near control values and an increase in the total swimming time was observed. W. somnifera is a potent antistressor agent in the crude form. Journal of Ethnopharmacology 64 (1999) 91–93

 Amla (Emblica officinalis)

Amla has tridoshar properties and it is a well-known rasayana drug. In a study, the antidepressant activity of E. officinalis (EO) in TST and FST was evaluated and found that its antidepressant activity was superior to that of the standard drug imipramine. Therefore, it was concluded that EO has the potential to be used as an adjuvant in the treatment of depression and other mood disorders. International Journal of Applied Biology and Pharmaceutical Technology. Volume: I: Issue-2: Aug-Oct -2010

 Jatamansi (Nardostachys jatamansi)

Jatamansi has tridosha balancing properties and exerts calming effect on mind and reduces restlessness. Studies suggest that this herb also acts as a powerful antidote for sleeplessness and helps enhance the quality of sleep. A study was undertaken to evaluate the antidepressant activity of  N. jatamansi extract. The finding suggests that N. jatamansi extract has dose dependent antidepressant activity and can also be used in patients suffering from depression due to sleep disturbances. Der Pharmacia Lettre, 2010, 2(5): 441-449

Jatamansi (Nardostachys jatamansi) and Sugandhbala (Valeriana wallichii)

In a clinical study the effect of Tagara/ Sugandhbala (Valeriana wallichii) and Jatamansi (Nardostachys jatamansi) in the management of Anidra (Insomnia) was evaluated. The patients  were randomly selected from Out Patient Department and In Patient Department of Manasa Roga. Tagara Churna and Jatamansi Churna was administered for a period of 1 month. Both the groups showed good results, but Tagara group showed better results in comparison to Jatamansi group. Ayu. 2015 Jan-Mar; 36(1): 46–49.

 Yastimadhu (Glycyrrhiza glabra)

Yastimadhu is an efficient brain tonic and it increases the circulation in the CNS system. In a study, laboratory model was treated with G. glabra extract and anxiolytic activity was assessed using different paradigms. Diazepam orondansetron served as standard anxiolytic agents. In results, the extract of roots and rhizomes of G. glabra possesses anxiolytic activity. Journal of Natural Remedies, Vol. 1/2 (2001) 130 – 134

 Vacha (Acorus calamus)

The experimental study on animal models was evaluated to check the antidepressant action of plant drug Vacha. The experimental study was done in rats to evaluate their Open Field Behavior (OFB) and High Plus Maze (HPM) before and after feeding Vacha. In results, Vacha has shown antidepressant effects in animal model of depression. Ayu. 2010 Apr-Jun; 31(2): 153–158.

Bhrami (Bacopa monnieri)

Bhrami is a commonly used Ayurvedic drug for mental disorders. The extract of Brahmi was reported  to have significant anti-oxidant  and Anxiolytic activity. It also improves memory retention in Alzheimer's disease. In a study B. monniera was investigated for potential antidepressant activity in rodent models of depression. The extract was found to have significant antidepressant activity in forced swim and learned helplessness models of depression and was comparable to that of imipramine.

Anxiety and depression are two of the most common mental health problems. These psychological problems can last longer for six months and more and can affect normal activities, job performance and relationships. According to Ayurveda, the imbalance of Manas guna and tridoshas are the causative factor of various psychological problems such as anxiety and depression.

Andemac tablet is the herbal formulation which is helpful in treating various types of psychological disorders. Andemac is formulated by the combination of Ayurvedic rasayana (Rejuvenator) drugs which provides strength to the mind.

  • Medhya rasayana drugs such as Mandukparni, Yashtimadhu and Brahmi promotes “Buddhi” and “Manas” by correcting the disturbances of “Raja” and “Tama”. They also have adaptogenic and anxiolytic effects.
  • Other class of Rasayana herbs like Ashwagandha, Vacha, Sugandhbala and Amla has Antistressor, anti-depressant and mild tranquilizer action therefore, effective in cases of mixed anxiety depression and associated symptoms.
  • The Brain rejuvenator and tonic property of Andemac provides strength to brain and helps to treat anxiety and depression by eliminating its root cause.
  • MALE REPRODUCTIVE HEALTH
  • SPERM ABNORMALITY
  • REVIFERT