PRIMALIV SYRUP

(If you are suffering from Indigestion, constipation, hyperacidity or High Uric acid levels in blood whose cause is unknown, indicates that you may have some problem in the Liver)

The liver is a vital organ in human body. In Ayurveda liver is known as “Yakrut” and its embryological origin is blood tissue.It performs an array of functions related to metabolism, immunity, digestion, detoxification, storage and distribution of various nutrients. Any problem with the liver can results in dysfunctioning of the liver. Some of the common liver problems are as follow:

  1. Hepatitis– Hepatitis refers to an inflammatory condition of the liver commonly caused by viral infection.
  2. Alcohol related liver disease– It is caused due to excessive alcohol consumption and results in cirrhosis.
  3. Non- alcoholic fatty liver disease– Due to eating of fast food or obesity, high levels of fats in the blood, the non-alcoholic fatty liver occurs.
  4. Drug induced and chemical induced hepatic injury-: It is caused by Anti TB drugs, Statins, chemotherapeutic agents, antiretroviral drugs and environmental pollutants.

Causes of liver diseases according to Ayurveda

According to ancient Ayurvedic Science imbalance of tridosha (body humorsi.eVata, Pitta &Kapha) are the main cause of diseased state. Ayurveda describes the liver as a fiery, hot organ and this is due to presence of Agni and pitta in the liver. Here, Agni is correlated to metabolic fire whereas pitta is correlated to Bile. The imbalance of pitta dosha and agni results in increased waste products or toxins and cell damage. This gives rise to udarroga (Udar is area where almost all organs especially related to digestion resides&Roga means disaese). If pitta dosh imbalance continues for a longer duration, serious liver disorders like jaundice, hepatitis, cirrhosis and cancer may develop.

Reasons of Pitta imbalance:

The Imbalance of tridosha can happen by dietary indiscrimination like eating pitta aggravating foods such as junk food and processed food items, alcohol abuse, stress and lack of sleep etc. Change in season and improper exercise can also result in imbalance of tridosha. Finally, this imbalance of dosha will result in Non- alcoholic fatty liver disease (NAFLD), Alcohol related liver disease, hepatitis, jaundice, cirrhosis and even death if not treated in time.

Pitta imbalances are classically hot and inflammatory in nature that’s why its equilibrium should be maintained to avoid any damage to the liver.

 

Junk food or processed food contains refined sugars and trans-fats which can cause a fatty build up in the liver. Packed foods and baked goods contain high trans-fat and sugars that make you more likely to gain weight. Even if you are not overweight but you are taking junk food on regular basis, there are high chances of development of fatty liver disease.

The overuse of refined sugars and trans-fats results in accumulation of excessive fat in liver cells (hepatocytes) which further leads to a condition fatty liver. The harmful effect of fast food on the body is also related to the formation of free radicals. Free radicals can cause damage to cells in the body by reacting with molecules in cell.

Similarly, the persons which are physically inactive but are on high calorie diet have increased incidence of liver disease. Moderate exercise is a healthy practice. However, exhaustive exercise generates free radicals leading to liver damage.

 

When liver is rapidly abused and not given a chance to recover then the damage become irreversible and progressive. So, the safeguard against liver disease is to prevent further liver damage by opting Hepatoprotectives and hepatostimulants.

Each 5 ml of syrup contains

Aqueous extract derived from:

Punarnava 125mg, Sarpunkha 100mg, Bhumiamlaki 100mg, Rohitak100 mg, Tulsi 100mg, Bhangra 100mg, Parpata 75mg, Kasni 50mg, Kutki 40mg,Chitrakmool  35mg, Shunthi 16.67mg, Marich 16.67mg, Pippali 16.67mg

Milk Thistle(Silybummarianum):

It is arguably the most commonly used medication for various liver diseases. It is a mixture of flavonolignans (Isosilybin A, Isosilybin B, Silybin A, Silybin B, Isosilychristin, Silychristin and Silydianin) and a flavonoid (Taxifolin).

It acts as a hepatoprotective by-

  • Exerting membrane stabilizing and antioxidant activity.
  • Promotes liver cell regeneration
  • Reduces inflammatory reactions
  • Inhibits fibrogenesis inliver
  • Increase protein synthesis in hepatocytes by stimulating RNA polymerase activity.

Punarnava(Boerhaviadiffusa):

In Ayurveda, Punarnava is known to be used as Sothaghna (anti-inflammatory) and Rasayana (rejuvenator). It has a pittahar action. It also has proved studies which show hepatoprotective action of Punarnava. The studies have shown the following positive responses in the treatment of liver diseases-

  • Elevation in the decreased levels of antioxidant
  • Elevated levels of liver marker enzymes.

Sarpunkha(Tephrosiapurpurea):

It has an antioxidant and free radical scavenging property. It reduces the elevated serum bio-marker levels (SGOT, SGPT and bilirubin) in the body and therefore, helps in proper functioning of Liver.

Bhumiamlaki (Phyllanthusniruri):

In Ayurvedic literature, Bhumiamlaki is known to be used as Kapha pittahara (which relieves the Kapha Pitta dosha), Kaamalahar (Which cures jaundice). Bhumiamla provides synergetic effect when given with Silymarin. It provides hepatoprotective action as it normalizes ROS (Reactive oxygen species) by their high antioxidant content and attenuating endogenous antioxidant enzymes to their normal level and stimulates the liver repair mechanism.

Rohitak (Tecomellaundulata):

It has been used in the indigenous systems of medicine for liver, spleen and abdominal complaints.

Tulsi(Ocimum sanctum):

It has been traditionally regarded as possessing rejuvenating, tonic and vitalizing properties that contribute to longevity and a healthy life. It also has detoxification properties which improves the elimination of toxic chemicals and act as hepatoprotective agent. Tulsi is enriched with various phyto chemicals.

Constituents like euginol, flavonoids and ursolic acid have free radical scavenging and anti-lipoperoxidative effect.

A study had shown that when alcoholic extract of tulsi plant administered orally, it exhibited hepatoprotective effect against Paracetamol, carbon tetrachloride and anti-tuberculosis drugs induced liver injury in albino rats.

Bhringraj(Ecliptaalba):

Bhringraj helps in detoxification of Liver and works as hepatic stimulant. It has Katu (pungent) and Tikta (bitter) taste. It improves overall liver health.

The components of E.albalike wedelo-lactone, demethyl-wedelolactone and saponins reduced fat deposition, mononuclear infiltration, and necrotic foci and stimulated liver cell regeneration.

Parpata(Fumariaparviflora):

Parpata is having kapha pittahar properties and bitter taste. According to classical text it is used in jaundice. Monomethyl fumarate is one of its active constituent of F. parviflora which is characterized as hepatoprotective and hepato stimulant agent.

Kasani(Cichoriumintybus):

Kasani has pitta balancing properties. In Ayurveda kasani has been used in treatment of various hepatic disorders.

A study results ascertain that C. intybus possess significant hepatoprotective activity against CCl4- induced hepatotoxicity. There were significant changes in serum biochemical parameters such as ALT, AST, ALP, bilirubin, albumin, total protein, and γ -glutamyltransferase (GGT) in carbon tetrachloride intoxicated rats, which were restored towards normal values in C. intybus-treated animals.

Kutki(PicrorhizaKurroa):

It is an established herbal remedy for variety of disease ranging from indigestion to hepatitis. Modern clinical studies have confirmed the efficacy and safety of Picrorhiza kurroa for the treatment of liver disease. Pharmacologically, Kutkin (Picrosides and kutkosides) has hepatoprotective activity. The therapeutic activity of the drug may be based on two mechanisms:

  • Kutkin alter the structure of the outer membrane of the hepatocytes in such a way as to prevent penetration of the liver toxin into the interior of the cell.
  • Kutkin stimulate the action of nucleolar polymerase A, resulting in ribosomal protein synthesis and, thus stimulates the regenerative ability of the liver and formation of new hepatocytes.
  • Apocynin, is one of its constituents, has been found to exhibit powerful anti- inflammatory effects on a variety of inflammatory models.

Chitrakmool(Plumbagozeylanica):

Chitrakmool has bitter taste therefore it is beneficial in liver problems. It helps in proper functioning of the liver. Several phytoconstituents viz., tri-terpenes, sterols, zeylonone of Plumbagozeylanica have been found effective in the hepato-protection against paracetamol induced hepatic toxicity. Administration of P. zeylanica decreased the level of bilirubin and increased the level of protein suggesting that it offered protection.

  • It also significantly decreased serum lipid profile in paracetamol toxicity induced rats because of its hypolipidemic effects and supplementation enhanced esterification effect through hepato-protective property by inhibiting the free radicals effect on liver cells.
  • γ‐glutamyltransferase (GGT) level were maintained by Plumbagozeylanica treatment due to its antioxidant activity.
  • Treatment with P. zeylanica decreased the serum levels of SGOT and SGPT towards the respective normal value that is an indication of stabilization of plasma membrane as well as repair of hepatic issue.

Sunthi(Zingiberofficinale):

Ginger plays an important role in traditional Indian Ayurvedic medicine. It has a large variety of pharmacological activities such as antibacterial, antioxidant, and anti-inflammatory. It has been reported to improve various gastrointestinal illnesses and immunologic dysfunction.

Several studies have shown the effect of ginger upon hepatotoxicity induced in albino rats by the anticancer drug, adriamycin (ADR). Treating animals with water extract of ginger led to an improvement in the histological changes induced by adriamycin together with significant decrease in ALT and AST activity. Moreover, ginger reduced the level of malondialdehyde and increased the activity of superoxide dismutase.

Marich(Piper nigrum):

It is one of the most commonly used spices among various spices. Piperine exhibits diverse pharmacological activities like anti-hypertensive, anti-oxidant, anti-tumor, anti-inflammatory, hepato-protective, immuno-modulatory, anti-apoptotic etc. It contains abundant amount of piperine alkaloids. Piperine alkaloids have been implicated in Hepatoprotective activity. In a study it was found that the levels of hepatic biomarkers (TG, AST, ALT, ALP, and Bilirubin) were restored.

  • There was also a significant increase in the levels of SOD, CAT, and GSH.

Pippali(Piper longum):

Pippali is one of the potent herbal drugs which can improve the regeneration process by restricting fibrosis and having hepato-protective action. It contains various alkaloids like piperine, piperlongumine, piperlonguminine, etc. which helps in the regeneration of hepatocytes. Additionally, it acts as bioavailability enhancer.

  • Various studies have shown that treatment with the ethanolic extract of P. longuminhibits liver fibrosis induced by carbon tetrachloride (CCl4).
  • An evident decrease in the level of serum enzymes, total bilirubin, and direct bilirubin was also observed.

Himsra(Capparisspinosa):

  • It contains p- methoxy benzoic acid which is a potent hepato protective.
  • It prevents elevation of malondialdehyde (biomarker for oxidative stress) levels in plasma and hepatic cells.
  • It inhibits the ALT and AST enzyme levels.

Liver is the organ that helps in number of functions such as detoxification, synthesis of proteins and production of biochemicals important for digestion and growth of an individual. Liver dysfunction also affects the functioning of other organs such as Kidneys and various metabolic processes like digestion; detoxification etc

PRIMALIV is the unique Herbal formulation containing Silymarin along with other 14 herbs that offers multiple benefits like hepato-protective, hepato-stimulant, and antioxidant. Primaliv syrup is the only Herbal hepatoprotective with Milk Thistle (Silymerine) benefits. It provides both curative and preventive effect.

  • Milk Thistle (Silymarin) in Primaliv protects the liver from further damage and helps in regeneration of liver cells so that it can be cured from the damaged condition.
  • The other herbs such as Kutaki, Bhumiamalaki, Punarnava, Kasani, Tulsi, Chitrakmool, Pippali, Marich, Himsra and Bhringraj act as hepatoprotective and as an antioxidant that helps to protect the liver by balancing the liver enzymes so that its recovery can be fasten up.
  • Bhringraj, Sarpunkha and Parpata are the hepatostimulant that modulates the proper functioning of the liver. They also stimulate the repair mechanism of the liver.

Primaliv is used to treat various liver conditions like early liver cirrhosis, fatty liver, hepatitis, jaundice and anorexia. It can be a logical adjuvant to various treatments like chemotherapy, haemodialysis and anti-TB treatment. Primaliv syrup hastens recovery period & ensure early restoration of liver functions in infective hepatitis. Thus, counteracts the root cause of liver problems, and improves liver function.

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